MYO3B

myosin IIIB

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000071909
UniProt:: Q8WXR4
OMIM:: 610040

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.44) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: abnormal bone structure, increased bone mineral content, decreased leukocyte cell number

Subcellular localization

cilia

References: PMID:19332056

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

Mediates movement along actin filaments in the cell (26098909). Prevents photoreceptor loss of function caused by Myo3A defects, as it could provide functional redundancy for Myo3A (19332056 ).

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