MYO3B

myosin IIIB

Ensembl:
ENSG00000071909
UniProt:
Q8WXR4
OMIM:
610040

Cilia effects upon perturbation of MYO3B

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.44) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal bone structure, increased bone mineral content, decreased leukocyte cell number
Mouse ciliopathy phenotype:
increased heart weight, convulsive seizures

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Mediates movement along actin filaments in the cell (26098909). Prevents photoreceptor loss of function caused by Myo3A defects, as it could provide functio l redundancy for Myo3A (19332056 ).