NAA10

Cilia effects upon perturbation of NAA10

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.43) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

abnormal skin morphology, enlarged spleen, abnormal spleen morphology, increased grip strength, small spleen, decreased circulating bilirubin level, abnormal coat/hair pigmentation, improved glucose tolerance, abnormal semil vesicle morphology, abnormal ovary morphology, increased lean body mass, increased circulating alkaline phosphatase level, abnormal lymph node morphology, enlarged epididymis, abnormal trachea morphology, decreased heart weight, enlarged lymph nodes, decreased total body fat amount, abnormal eye morphology

Mouse ciliopathy phenotype:

abnormal heart morphology, enlarged kidney, abnormal adrel gland morphology, abnormal kidney morphology, hydrocephaly, hydrometra, small kidney, abnormal uterus morphology, abnormal brain morphology, enlarged heart, abnormal liver morphology, microphthalmia, small testis, abnormal testis morphology

Human ciliopathy phenotype:

Premature aging appearance-developmental delay-cardiac arrhythmia syndrome; Microphthalmia - ankyloblepharon - intellectual disability

Subcellular localization

cilia associated gene, nucleus

Functional category

• Ciliary assembly/disassembly

Function

ARD1 and T1 colocalized with MTs in cultured hippocampal neurons and fibroblasts, and that ARD1 activity post-translatio lly mediated acetylation in the purified tubulin fraction in vitro. the N-acetyltransferase activity of the ARD1– T1 complex regulates dendritic arborization in neuro l cells. ARD1 and T1 colocalize with MTs and also colocalized with acetylated α-tubulin in neuro l dendrites in dendrites( 19090811).