NANOG

Nanog homeobox

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000111704
UniProt:: Q9H9S0
OMIM:: 607937
Synonyms:: FLJ12581, FLJ40451

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

References: PMID:32168958

Functional category

Ciliary assembly/disassembly
Protein processing & maturation
Transcription regulation

Function

Cytoplasmic NOG was unevenly distributed at the centrosome pair during the cell cycle and colocalized with the distal region of the mother centriole, and its presence was markedly associated with centriole maturation. Along with the finding that the centrosomal localization of NOG/ NOGP8 was detected in various tumor and non-tumor cell types, these results provide the first evidence suggesting a common centrosome-specific role of NOG(32168958).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.