NAT1

N-acetyltransferase 1

Ensembl:: ENSG00000171428
UniProt:: P18440
OMIM:: 108345
Synonyms:: AAC1

Cilia effects upon perturbation of NAT1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, cytosol, ribosome

Functional category

Ciliary assembly/disassembly

Function

ARD1 and T1 colocalized with MTs in cultured hippocampal neurons and fibroblasts, and that ARD1 activity post-translatio lly mediated acetylation in the purified tubulin fraction in vitro. the N-acetyltransferase activity of the ARD1– T1 complex regulates dendritic arborization in neuro l cells.ARD1 and T1 colocalize with MTs and also colocalized with acetylated α-tubulin in neuro l dendrites in dendrites( 19090811).

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