NAV1

neuron navigator 1

Ensembl:
ENSG00000134369
UniProt:
Q8NEY1
OMIM:
611628
Synonyms:
DKFZP781D0314, FLJ12560, FLJ14203, KIAA1151, MGC14961

Cilia effects upon perturbation of NAV1

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-13.14) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.27) PMID:41160700

Phenotypes

Mouse phenotype:
hyperactivity, increased freezing behavior, decreased grip strength, abnormal skin morphology, prolonged rr interval, abnormal spleen morphology, decreased heart rate, enlarged spleen, decreased brain size
Mouse ciliopathy phenotype:
small kidney, abnormal kidney morphology, abnormal brain morphology

Subcellular localization

cilia, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism

Function

AnkG and v1.2 but not v1.6 or Kv1.1 localized to cilia with 5-HT6R upregulation (31186137).