NCBP2

nuclear cap binding protein subunit 2

Ensembl:
ENSG00000114503
UniProt:
P52298
OMIM:
605133
Synonyms:
CBC2, CBP20, NIP1

Cilia effects upon perturbation of NCBP2

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.49) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=254, lfc=-4.96) PMID:30270045

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, increased anxiety-related response, embryonic lethality prior to organogenesis

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

NCBP2 has localized in basal body.