NCS1

neuronal calcium sensor 1

Ensembl:
ENSG00000107130
UniProt:
P62166
OMIM:
603315
Synonyms:
FREQ, NCS-1

Cilia effects upon perturbation of NCS1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.08) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased grip strength, abnormal cornea morphology, preweaning lethality, incomplete penetrance, decreased total reti thickness, increased circulating phosphate level

Subcellular localization

basal body, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

NCS1 and C3ORF14 proteins localized at the distal appendage (36711481).