NDE1

nudE neurodevelopment protein 1

Ensembl:
ENSG00000072864, ENSG00000275911
UniProt:
Q9NXR1
OMIM:
609449
Synonyms:
FLJ20101, NDE, NUDE

Cilia effects upon perturbation of NDE1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.07) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Negative regulator of ciliary length via interaction with LC8. Its depletion causes longer cilia and a delay in cell cycle re-entry (26880200, 21394081).