NDRG1

N-myc downstream regulated 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000104419
UniProt:: Q92597
OMIM:: 605262
Synonyms:: CAP43, DRG1, NDR1, RTP, TDD5

Cilia effects upon perturbation of NDRG1

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

centrosome, cytosol, flagella, nucleus

References: PMID:25613900

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation

Function

NDRG1 localized to flagella (25613900)

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