NDRG1

N-myc downstream regulated 1

Ensembl:
ENSG00000104419
UniProt:
Q92597
OMIM:
605262
Synonyms:
CAP43, DRG1, NDR1, RTP, TDD5

Cilia effects upon perturbation of NDRG1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

centrosome, cytosol, flagella, nucleus

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology

Function

NDRG1 localized to flagella (25613900)

Model organism evidence

Xenopus (1 reference)

Using the Xenopus laevis embryo, we show that Dishevelled (Dvl), a key Wnt signaling scaffold that is critical to proper ciliogenesis, interacts with Drg1 (developmentally regulated GTP-binding protein 1).

PMIDs: 31270137