NDUFA6

NADH:ubiquinone oxidoreductase subunit A6

Ensembl:
ENSG00000281013, ENSG00000184983, ENSG00000272765, ENSG00000273397, ENSG00000277365
UniProt:
P56556
OMIM:
602138
Synonyms:
B14, CI-B14, LYRM6, NADHB14

Cilia effects upon perturbation of NDUFA6

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, decreased heart rate, embryonic lethality prior to organogenesis, prolonged rr interval
Mouse ciliopathy phenotype:
thick ventricular wall

Subcellular localization

flagella, mitochondria

Functional category

  • Metabolism

Function

NDUFA6 has localized in flagella.