NDUFA8

NADH:ubiquinone oxidoreductase subunit A8

Ensembl:
ENSG00000119421
UniProt:
P51970
OMIM:
603359
Synonyms:
MGC793, PGIV

Cilia effects upon perturbation of NDUFA8

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.79) PMID:20393562

Phenotypes

Mouse phenotype:
increased grip strength, preweaning lethality, complete penetrance, decreased total reti thickness, decreased circulating sodium level, increased bone mineral content
Mouse ciliopathy phenotype:
abnormal reti blood vessel morphology, cataract, abnormal lens morphology

Subcellular localization

flagella, mitochondria

Functional category

  • Metabolism

Function

NDUFA8 has localized in flagella.