NDUFB11
NADH:ubiquinone oxidoreductase subunit B11
- Ensembl:
- ENSG00000147123
- UniProt:
- Q9NX14
- OMIM:
- 300403
- Synonyms:
- ESSS, NP15, NP17.3
Cilia effects upon perturbation of NDUFB11
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (5 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.89) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=962, lfc=-2.40) PMID:30270045
Phenotypes
- Human ciliopathy phenotype:
- Microphthalmia with linear skin defects syndrome
Subcellular localization
flagella, lysosomes, mitochondria
Functional category
- Metabolism
Function
NDUFB11 has localized in flagella.