NDUFS2

NADH:ubiquinone oxidoreductase core subunit S2

Ensembl:
ENSG00000158864
UniProt:
O75306
OMIM:
602985
Synonyms:
CI-49

Cilia effects upon perturbation of NDUFS2

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.67) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.47) PMID:41160700

Phenotypes

Mouse phenotype:
abnormal embryo size, preweaning lethality, complete penetrance, embryonic lethality prior to organogenesis, embryonic lethality prior to tooth bud stage

Subcellular localization

flagella, mitochondria, nucleus

Functional category

  • Metabolism

Function

NDUFS2 has localized in flagella.