NEDD1

NEDD1 gamma-tubulin ring complex targeting factor

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000139350
UniProt:
Q8NHV4
OMIM:
600372
Synonyms:
GCP-WD, TUBGCP7

Cilia effects upon perturbation of NEDD1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased eosinophil cell number, preweaning lethality, complete penetrance, abnormal coat/ hair morphology, decreased circulating fructosamine level, embryonic lethality prior to organogenesis, increased circulating potassium level

Subcellular localization

basal body, centrosome, cytosol

References: PMID:27062996

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Pk3 is required for γ-tubulin and Nedd1 recruitment to the basal body, indicating a new function in basal body organization. This function of Pk3 may involve Wilms tumor protein 1-interacting protein (Wtip), which physically associates with and cooperates with Pk3 to regulate ciliogenesis.