NEDD9
neural precursor cell expressed, developmentally down-regulated 9
- Ensembl:
- ENSG00000111859
- UniProt:
- Q14511
- OMIM:
- 602265
- Synonyms:
- CAS-L, CASS2, HEF1
Cilia effects upon perturbation of NEDD9
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- Decreased
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
basal body, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Cell migration & adhesion
Function
Transducer of integrin attachment, migration, and anti-apoptotic sig ls at focal adhesions. Promotes activation and stabilisation of AurA, which phosphorylates ciliary HDAC6 to induce disassembly of the primary cilium. (17604723).
Model organism evidence
Mus musculus (2 references)
However, the HIF-2α also could promote primary cilia loss through HIF-2α/AURKA (Aurora kinase A)/NEDD9 pathway.
This cystogenic effect is associated with striking morphological defects in the cilia of Pkd1(-/-);Nedd9(-/-) mice, associated with specific loss of ciliary localization of adenylase cyclase III in the doubly mutant genotype.