NEDD9

neural precursor cell expressed, developmentally down-regulated 9

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000111859
UniProt:: Q14511
OMIM:: 602265
Synonyms:: CAS-L, CASS2, HEF1

Cilia effects upon perturbation of NEDD9

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Longer cilia
Overexpression effect:: Decreased

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

References: PMID:17604723, PMID:20864688

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Cell migration & adhesion

Function

Transducer of integrin attachment, migration, and anti-apoptotic signals at focal adhesions. Promotes activation and stabilisation of AurA, which phosphorylates ciliary HDAC6 to induce disassembly of the primary cilium. (17604723).

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