NEK10

Cilia effects upon perturbation of NEK10

Cilia number / % ciliated:

Unknown

Loss-of-function effect:

Shorter cilia

Overexpression effect:

Unknown

Ciliogenesis screen results (2 screens)

• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.11) PMID:26167766

Phenotypes

Mouse phenotype:

abnormal skin coloration

Ciliopathy associations

• Primary Ciliary Dyskinesia

References: PMID:31959991

Subcellular localization

basal body, mitochondria

References: PMID:31959991, PMID:29581457, PMID:32414360, PMID:33064774

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

NEK10 is a ciliated-cell specific kinase that regulates the motile ciliary proteome to promote ciliary length, and its deficiency produces short motile cilia . Required for effective airway mucociliary clearance (31959991). NEK1 localisation is mediated by its interaction with PCM1 (29581457).Mutations are associated with primary ciliary dyskinesia (32414360). Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function (33064774)