NEK10

NIMA related kinase 10

Ensembl:
ENSG00000163491
UniProt:
Q6ZWH5
OMIM:
618726
Synonyms:
FLJ32685

Cilia effects upon perturbation of NEK10

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Shorter cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (2 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.11) PMID:26167766

Phenotypes

Mouse phenotype:
abnormal skin coloration

Ciliopathy associations

  • Primary Ciliary Dyskinesia

Subcellular localization

basal body, mitochondria

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

NEK10 is a ciliated-cell specific ki se that regulates the motile ciliary proteome to promote ciliary length, and its deficiency produces short motile cilia . Required for effective airway mucociliary clearance (31959991). NEK1 localisation is mediated by its interaction with PCM1 (29581457).Mutations are associated with primary ciliary dyskinesia (32414360). Mutation of NEKL-4/NEK10 and TTLL genes suppress neuro l ciliary degeneration caused by loss of CCPP-1 deglutamylase function (33064774)

Model organism evidence

C. elegans (4 references)

This study focuses on the localized activation of OSM-3, an intraflagellar transport kinesin crucial for the assembly of ciliary distal segments in Caenorhabditis elegans sensory neurons.

Intraflagellar transport (IFT) involves the coordinated transport of molecular motors and other proteins and is required for ciliogenesis and ciliary maintenance.

PMIDs: 40272473, 39135985, 38767515, 38405845

Mus musculus (1 reference)

This represents a divergent function within the Nek family, whose other members are serine-threonine kinases involved in different elements of the centrosomal cycle, primary cilia function, and DNA damage responses.

PMIDs: 38683979