NEK4

NIMA related kinase 4

Ensembl:
ENSG00000114904
UniProt:
P51957
OMIM:
601959
Synonyms:
NRK2, PP12301, STK2

Cilia effects upon perturbation of NEK4

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.06) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.04, ciliated=22.0%) PMID:26595381

Subcellular localization

basal body, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Transition zone

Function

Interacts with RPGRIP1 and RPGRIP1L to regulate cilium integrity and/or assembly. It associates with ciliary rootlets to regulate cilia stability