NEK6

NIMA related kinase 6

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000119408
UniProt:: Q9HC98
OMIM:: 604884
Synonyms:: SID6-1512

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

Chronic Obstructive Pulmonary Disease

References: PMID:33639936

Subcellular localization

centriolar satellites, cytosol, nucleoplasm

References: PMID:33639936, PMID:17727698, PMID:16280549

Functional category

Metabolism

Function

This bio-informatics approach unveils yet undescribed cilia and ciliopathy genes associated with chronic obstructive pulmonary disease (COPD) including NEK6 and PROM2 that may contribute to the pathology, and suggests a COPD endotype exhibiting ciliopathy features (CiliOPD) (PMID: 33639936). Interestingly, the clade of Nek6/7 is not found fungi, suggesting a role of Nek6/7 in ciliary function (PMID: 17727698, PMID: 16280549).

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