NEK6

NIMA related kinase 6

Ensembl:
ENSG00000119408
UniProt:
Q9HC98
OMIM:
604884
Synonyms:
SID6-1512

Cilia effects upon perturbation of NEK6

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Chronic Obstructive Pulmonary Disease

Subcellular localization

centriolar satellites, cilia associated gene, cytosol, nucleoplasm

Functional category

  • Metabolism

Function

This bio-informatics approach unveils yet undescribed cilia and ciliopathy genes associated with chronic obstructive pulmonary disease (COPD) including NEK6 and PROM2 that may contribute to the pathology, and suggests a COPD endotype exhibiting ciliopathy features (CiliOPD) (PMID: 33639936). Interestingly, the clade of Nek6/7 is not found fungi, suggesting a role of Nek6/7 in ciliary function (PMID: 17727698, PMID: 16280549).

Model organism evidence

C. elegans (3 references)

Here, we show that a NEver in mitosis Kinase NEKL-3 directly phosphorylates a flexible elbow region between two coiled-coil domains connecting the motor head and tail of an intraflagellar transport kinesin, OSM-3.

This study focuses on the localized activation of OSM-3, an intraflagellar transport kinesin crucial for the assembly of ciliary distal segments in Caenorhabditis elegans sensory neurons.

PMIDs: 40497557, 40272473, 37099601

Mus musculus (1 reference)

Lastly, the percentage of mutant MEF cells bearing primary cilia (PC) was low, whereas a cell population having two cilia appeared in the mutant MEFs.

PMIDs: 20473324