NEK9

NIMA related kinase 9

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000119638
UniProt:
Q8TD19
OMIM:
609798
Synonyms:
DKFZP434D0935, MGC16714, NEK8, NERCC, NERCC1

Cilia effects upon perturbation of NEK9

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia
Overexpression effect:
No effect

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.86) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cytosol, nucleus

References: PMID:34078910

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

NEK9 interacts with MYH9 (also known as myosin IIA), which has been implicated in inhibiting ciliogenesis through stabilization of the actin network. MYH9 accumulates in NEK9 LIR mutant cells and mice, and depletion of MYH9 restores ciliogenesis in NEK9 LIR mutant cells ( 34078910).