NEURL4

Cilia effects upon perturbation of NEURL4

Cilia number / % ciliated:

Incrased cilia number

Overexpression effect:

Increased

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased grip strength, enlarged spleen, absent semil vesicle, abnormal spleen morphology, decreased prepulse inhibition, abnormal gallbladder morphology, decreased leukocyte cell number, abnormal eye morphology, small spleen, decreased heart weight, decreased total body fat amount, increased lean body mass, abnormal skin morphology, enlarged gallbladder

Mouse ciliopathy phenotype:

eye hemorrhage, abnormal liver morphology, small kidney, abnormal kidney morphology

Subcellular localization

basal body, cilia

Functional category

• Ciliary assembly/disassembly

Function

Controls CP110 levels at mother centriole. It transiently traslocates to mother centriole to remove CP110 and facilitate proximily between both centrioles and and promote axoneme formation (28385950). Promotes ubiquitylation of CP110 to maintain centrosome homeostasis and prevent the formation of ectopic microtubular organizing centres (22441691).