NFAT5
nuclear factor of activated T cells 5
- Ensembl:
- ENSG00000102908
- UniProt:
- O94916
- OMIM:
- 604708
- Synonyms:
- KIAA0827, NF-AT5, NFATL1, NFATZ, OREBP
Cilia effects upon perturbation of NFAT5
- Cilia number / % ciliated:
- Decreased cilia number
Ciliogenesis screen results (6 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.38) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=544, lfc=-2.53) PMID:30270045
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.87) PMID:41160700
Phenotypes
- Mouse phenotype:
- preweaning lethality, incomplete penetrance, improved glucose tolerance, increased circulating chloride level, decreased hematocrit, increased circulating sodium level
- Mouse ciliopathy phenotype:
- increased circulating bilirubin level
Subcellular localization
basal body, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Cell migration & adhesion
Function
TonEBP controlled the expression and activity of aurora ki se A, TonEBP overexpression inhibited the loss of CP110 from the mother centrioles during the early stages of primary cilia assembly, and TonEBP regulated the localization of PCM1 and AZI1 (38961488).
Model organism evidence
Danio rerio (1 reference)
Here we provide in vivo evidence that melanoma cell adhesion molecule (MCAM) coordinates AB polarity-driven lumenogenesis and c-Jun N-terminal kinase (JNK)/PCP-dependent ciliogenesis.
PMIDs: 28589943
Xenopus (1 reference)
Here we provide in vivo evidence that melanoma cell adhesion molecule (MCAM) coordinates AB polarity-driven lumenogenesis and c-Jun N-terminal kinase (JNK)/PCP-dependent ciliogenesis.
PMIDs: 28589943