NFE2L1

NFE2 like bZIP transcription factor 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000082641
UniProt:
Q14494
OMIM:
163260
Synonyms:
FLJ00380, LCR-F1, NRF-1, NRF1, TCF11

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.89) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.76) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Spondylometaphyseal Dysplasia

References: PMID:34999280

Subcellular localization

cytosol, nucleoplasm

References: PMID:31554934

Function

NRF1 compensating for NRF2 loss in specific cell types. If so, one would expect Nfe2l1-Nfe2l2 double knockout mice to display cilia and Hh-related phenotypes (PMID: 31554934).