NGFR

Cilia effects upon perturbation of NGFR

Ciliogenesis screen results (4 screens)

• Kim2016: No effect
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.66) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

increased startle reflex, abnormal digit morphology, abnormal gait, decreased thigmotaxis, decreased circulating triglyceride level, limb grasping, decreased locomotor activity, preweaning lethality, incomplete penetrance, increased circulating phosphate level, abnormal eye morphology, abnormal behavior, tremors, decreased circulating alkaline phosphatase level

Mouse ciliopathy phenotype:

abnormal reti morphology

Subcellular localization

basal body, cytosol, nucleus

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Neurogenesis & migration
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Axon guidance & growth
• Transcription regulation

Function

Likely to provide sig ls to drive granule cell progenitor proliferation (22995307). It may be involved in neurogenesis and memory- encoding functions in dentate gyral granule cells (20875398).