NIM1K

NIM1 serine/threonine protein kinase

Ensembl:: ENSG00000177453
UniProt:: Q8IY84
Synonyms:: MGC42105, NIM1

Cilia effects upon perturbation of NIM1K

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=736, lfc=-2.32) PMID:30270045

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly

Function

NIM1K and UBL3 localize inside the cilium in a prenylation-dependent manner (36672247).

Model organism evidence

Mus musculus (1 reference)

Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D (PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human ciliopathy Joubert Syndrome (JBTS22) and retinal degeneration in mice.

PMIDs: 36672247

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