NIN

Cilia effects upon perturbation of NIN

Ciliogenesis screen results (5 screens)

• Kim2016: No effect
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.18) PMID:20393562

Phenotypes

Mouse phenotype:

hyperactivity, decreased prepulse inhibition, decreased anxiety-related response, decreased startle reflex

Mouse ciliopathy phenotype:

abnormal auditory brainstem response

Subcellular localization

basal body, centrosome, microtubules, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Neurogenesis & migration

Function

Also called ninein. Interacts with gamma-tubulin-containing complexes. It plays roles in promoting microtubule- nucleation and -anchoring processes at the centrosome (15784680).

Model organism evidence