NIN

ninein

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000100503
UniProt:
Q8N4C6
OMIM:
608684

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.18) PMID:20393562

Phenotypes

Mouse phenotype:
hyperactivity, decreased prepulse inhibition, decreased anxiety-related response, decreased startle reflex

Subcellular localization

basal body, centrosome, microtubules, nucleus

References: PMID:41005307, PMID:15784680

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration

Function

Also called ninein. Interacts with gamma-tubulin-containing complexes. It plays roles in promoting microtubule- nucleation and -anchoring processes at the centrosome (15784680).