NINL

ninein like

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000101004
UniProt:: Q9Y2I6
OMIM:: 609580
Synonyms:: KIAA0980, NLP

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased mean corpuscular volume, hyperplasia

Subcellular localization

basal body, cytosol, cilia, transition zone

References: PMID:41005307, PMID:18826961, PMID:26485514

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Protein processing & maturation
Signaling (Hedgehog, GPCRs, ion channels)

Function

Also called NLP. It is involved in microtubule nucleation, anchoring and outgrowth (18826961). NLP interacts with ciliopathy- associated proteins lebercilin, USH2A and CC2D2A. Interacts with DZANK1 in vesicle transport towards the photoreceptor outer segments and its development/maintenance, in photoreceptor cells (26485514).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.