NINL

ninein like

Ensembl:
ENSG00000101004
UniProt:
Q9Y2I6
OMIM:
609580
Synonyms:
KIAA0980, NLP

Cilia effects upon perturbation of NINL

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased mean corpuscular volume, hyperplasia

Subcellular localization

basal body, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Also called NLP. It is involved in microtubule nucleation, anchoring and outgrowth (18826961). NLP interacts with ciliopathy- associated proteins lebercilin, USH2A and CC2D2A. Interacts with DZANK1 in vesicle transport towards the photoreceptor outer segments and its development/mainte nce, in photoreceptor cells (26485514).

Model organism evidence

Mus musculus (1 reference)

Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis.

PMIDs: 33649372