NME3

NME/NM23 nucleoside diphosphate kinase 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000103024
UniProt:
Q13232
OMIM:
601817
Synonyms:
DR-NM23, NDPKC, NM23-H3

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.65) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, mitochondria

References: PMID:30111592

Functional category

  • Ciliary assembly/disassembly

Function

Facilitates DNA-repair mechanisms. Binds to several NPHPs, including NEK8, CEP164, and ankyrin repeat and sterile α motif domain- containing 6 (ANKS6). Required for determining left- right assymetry and ciliogenesis. Potential nephronophthisis disease gene (30111592 ).