NME5

NME/NM23 family member 5

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000112981
UniProt:: P56597
OMIM:: 603575
Synonyms:: NM23-H5, RSPH23

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.77) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.74) PMID:41160700

Phenotypes

Human ciliopathy phenotype:: ciliary dyskinesia, primary, 48, without situs inversus

Ciliopathy associations

Primary Ciliary Dyskinesia

References: PMID:32185794, PMID:31479451

Subcellular localization

basal body, cilia

References: PMID:41410385, PMID:42010243, PMID:41005307, PMID:21746835, PMID:24424412, PMID:32185794

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm

Function

Hydrocephalus and infertility due to dysfunctional motile cilia in KO mouse (21746835). Role in ciliary beating (24424412). Mutations cause of human PCD (32185794).

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