NME8

NME/NM23 family member 8

Ensembl:
ENSG00000086288
UniProt:
Q8N427
OMIM:
607421
Synonyms:
CILD6, DNAI8, NM23-H8, SPTRX2, TXNDC3

Cilia effects upon perturbation of NME8

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

  • Primary Ciliary Dyskinesia

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Also called TXNDC3, Candidate gene for PCD. Encodes a thioredoxine- nucleoside diphosphate ki se expressed in testis and respiratory epithelial cells. It is shown to have binding properties to ( 17360648). Human ortholog of the sea urchin IC1 gene that encodes a component of sperm outer dynein arms ( 19410201).