NME8

NME/NM23 family member 8

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000086288
UniProt:: Q8N427
OMIM:: 607421
Synonyms:: CILD6, DNAI8, NM23-H8, SPTRX2, TXNDC3

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Primary Ciliary Dyskinesia

References: PMID:17360648

Subcellular localization

cilia

References: PMID:41005307, PMID:17360648, PMID:19410201

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

Also called TXNDC3, Candidate gene for PCD. Encodes a thioredoxine- nucleoside diphosphate kinase expressed in testis and respiratory epithelial cells. It is shown to have binding properties to ( 17360648). Human ortholog of the sea urchin IC1 gene that encodes a component of sperm outer dynein arms ( 19410201).

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