NOS1

nitric oxide synthase 1

Ensembl:
ENSG00000089250
UniProt:
P29475
OMIM:
163731
Synonyms:
NNOS, NOS

Cilia effects upon perturbation of NOS1

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

Neuro l NOS(nNOS, NOS1) consistently localised to the ciliary compartment of ciliated ALI-cultured epithelial cells (n = 5 subjects) (Fig. 2b) and co-localised with the cilia marker 尾-tubulin [26], in the proximal part of the ciliary axoneme but not towards the distal portion(25460324).