NOS2

nitric oxide synthase 2

Ensembl:
ENSG00000007171
UniProt:
P35228
OMIM:
163730
Synonyms:
HEP-NOS, INOS, NOS, NOS2A

Cilia effects upon perturbation of NOS2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=794, lfc=0.71) PMID:30270045

Phenotypes

Mouse phenotype:
decreased thigmotaxis, abnormal eye anterior chamber depth

Subcellular localization

basal body, cytosol, nucleus, peroxisome

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Viral interactions

Function

The inducible NOS (iNOS, NOS2) showed some punctate immunostaining near to the base of the cilia(25460324).