NOTO

notochord homeobox

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000214513
UniProt:: A8MTQ0
OMIM:: 620695

Cilia effects upon perturbation of NOTO

Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Subcellular localization

cilia, nucleus, transition zone

References: PMID:21703454

Functional category

Ciliary assembly/disassembly
Transition zone
Transcription regulation

Function

Essential for ciliogenesis in the posterior notochord, and the establishment of left–right asymmetry (17884984). Transcription factor regulating expression of cilia genes through Foxj1 and Rfx3. Mutants have disorganised or incomplete axonemal (22357932).

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