NOTO
notochord homeobox
- Ensembl:
- ENSG00000214513
- UniProt:
- A8MTQ0
- OMIM:
- 620695
Cilia effects upon perturbation of NOTO
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585
Subcellular localization
cilia, nucleus, transition zone
Functional category
- Ciliary assembly/disassembly
- Transition zone
- Transcription regulation
Function
Essential for ciliogenesis in the posterior notochord, and the establishment of left鈥搑ight asymmetry (17884984). Transcription factor regulating expression of cilia genes through Foxj1 and Rfx3. Mutants have disorganised or incomplete axonemal (22357932).
Model organism evidence
Mus musculus (3 references)
Key regulators of motile ciliogenesis are the transcription factors FOXJ1 and NOTO, which are conserved throughout vertebrates.
The expression of the Noto, Rfx3, and Foxj1 transcription factors known to regulate ciliogenesis is greatly depleted in the mid-gastrula node of mutants, as is the expression of the Pkd1l1 gene required for cilia function.