NPFFR1

neuropeptide FF receptor 1

Ensembl:: ENSG00000148734
UniProt:: Q9GZQ6
OMIM:: 607448
Synonyms:: GPR147, NPFF1R1, OT7T022

Cilia effects upon perturbation of NPFFR1

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.49) PMID:41160700

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

Several GPCRs whose ligands are involved in feeding behavior, including prolactin-releasing hormone receptor (PRLHR), neuropeptide FF receptor 1 (NPFFR1), and neuromedin U receptor 1 (NMUR1), localized to the primary cilia(26053317).

Model organism evidence

Mus musculus (1 reference)

We found that several GPCRs whose ligands are involved in feeding behavior, including prolactin-releasing hormone receptor (PRLHR), neuropeptide FF receptor 1 (NPFFR1), and neuromedin U receptor 1 (NMUR1), localized to the primary cilia.

PMIDs: 26053317

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