NPM2

nucleophosmin/nucleoplasmin 2

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000158806
UniProt:: Q86SE8
OMIM:: 608073

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-6.14) PMID:41160700

Subcellular localization

nucleus

References: PMID:38457249

Functional category

Ciliary assembly/disassembly
Reproduction & sperm

Function

Both ARL3T31A and ARL3T31A/C118F groups exhibited a reduction in cilium formation, therefore, the decrease in cilium formation in these groups may be associated with the downregulation of LIMS2 and NPM2 ( 38457249).

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