NPY2R
neuropeptide Y receptor Y2
- Ensembl:
- ENSG00000185149
- UniProt:
- P49146
- OMIM:
- 162642
Cilia effects upon perturbation of NPY2R
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.63) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- increased spleen weight, abnormal locomotor behavior, enlarged spleen
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Transcription regulation
Function
Encodes a G protein-coupled receptors involved in energy homeostasis, and could be a major driver of hyperphagia- induced obesity in BBS (24316073).
Model organism evidence
Mus musculus (3 references)
The BBSome, a complex of eight Bardet-Biedl syndrome (BBS) proteins involved in cilia function, has emerged as an important regulator of energy balance, but the underlying cellular and molecular mechanisms are not fully understood.
Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control.