NPY2R

neuropeptide Y receptor Y2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000185149
UniProt:
P49146
OMIM:
162642

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.63) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased spleen weight, abnormal locomotor behavior, enlarged spleen

Subcellular localization

cilia

References: PMID:24316073

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

Encodes a G protein-coupled receptors involved in energy homeostasis, and could be a major driver of hyperphagia- induced obesity in BBS (24316073).