NPY5R

neuropeptide Y receptor Y5

Ensembl:
ENSG00000164129
UniProt:
Q15761
Synonyms:
NPYR5

Cilia effects upon perturbation of NPY5R

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.19) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased total body fat amount, increased circulating alkaline phosphatase level, decreased lean body mass, decreased locomotor activity, increased circulating hdl cholesterol level

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

Encodes a G protein-coupled receptors involved in energy homeostasis (24316073).

Model organism evidence

Mus musculus (1 reference)

Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.

PMIDs: 24316073