?

Subcellular localization

Ciliary associated gene, Nucleoplasm

Functional category

• Trafficking (BBSome
• small GTPases
• vesicular transport
• ATPases)

Function

Proteomics profiling of Ift27/Bbs19 mutant cilia correctly detected BBSome accumulation inside Ift27−/− cilia and revealed that β-arrestin 2 and the viral receptor CAR(NR1I3) are candidate cargoes of the BBSome. CAR-positive cilia were rarely found when staining for endogenous CAR (Figures 7D and 7E). However, when analyzing Ift27−/− mutants, the majority of cilia were clearly positive for CAR, even though the total levels of CAR were unchanged (Figures 7C–7E)(26585297).