NRAS

NRAS proto-oncogene, GTPase

Ensembl:
ENSG00000213281
UniProt:
P01111
OMIM:
164790
Synonyms:
N-RAS

Cilia effects upon perturbation of NRAS

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating hdl cholesterol level, increased circulating glucose level, preweaning lethality, complete penetrance
Mouse ciliopathy phenotype:
short tibia

Subcellular localization

cilia associated gene, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

EZH2 inhibition for promoting ciliogenesis are observed in the mouse melanoma models driven by Nras or Braf, supporting a general effect of melanoma oncogenes on ciliation ( 29990499).