NRCAM

neuronal cell adhesion molecule

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000091129
UniProt:
Q92823
OMIM:
601581
Synonyms:
BRAVO, KIAA0343

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.95) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.31) PMID:41160700

Phenotypes

Mouse phenotype:
increased fasting circulating glucose level, limb grasping

Subcellular localization

cilia

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Protein processing & maturation
  • Cell migration & adhesion
  • Axon guidance & growth

Function

The cell adhesion molecule NRCAM, which is involved in cell-cell contacts and axon outgrowth in the peripheral- and central nervous system (22182708) localized at cilia.