NRCAM

neuronal cell adhesion molecule

Ensembl:
ENSG00000091129
UniProt:
Q92823
OMIM:
601581
Synonyms:
BRAVO, KIAA0343

Cilia effects upon perturbation of NRCAM

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.95) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.31) PMID:41160700

Phenotypes

Mouse phenotype:
increased fasting circulating glucose level, limb grasping
Mouse ciliopathy phenotype:
convulsive seizures

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Protein processing & maturation
  • Cell migration & adhesion
  • Axon guidance & growth

Function

The cell adhesion molecule NRCAM, which is involved in cell-cell contacts and axon outgrowth in the peripheral- and central nervous system (22182708) localized at cilia.

Model organism evidence

C. elegans (1 reference)

Primary cilia are located at the dendritic tips of sensory neurons and house the molecular machinery necessary for detection and transduction of sensory stimuli.

PMIDs: 33460640