NRP2

neuropilin 2

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000118257
UniProt:
O60462
OMIM:
602070
Synonyms:
VEGF165R2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.32) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:28667171

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Axon guidance & growth
  • Transcription regulation

Function

NRP1 and NRP2 promote HH signaling by modulating GLI activator function ( 28667171).