NUBP1

NUBP iron-sulfur cluster assembly factor 1, cytosolic

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000103274
UniProt:
P53384
OMIM:
600280
Synonyms:
CIAO5, NBP1, NBP35

Cilia effects upon perturbation of NUBP1

Cilia number / % ciliated:
Incrased cilia number

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.69) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol

References: PMID:16638812, PMID:23807208

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism

Function

Nubp1 and Nubp2 interact with each other, but their individual knockdown, however, has differential effects on centrosome and spindle formation: while Nubp1 silencing qualitatively phenocopies KIFC5A silencing, also resulting in significant centrosome amplification throughout the cell cycle and the formation of multipolar spindles, Nubp2 appears to have a modulatory/accessory role for centriole arithmetics, in concert with KIFC5A and Nubp1 [16638812]. Nubp1 and Nubp2 localize on interphase centrioles in cycling cells and basal bodies in quiescent cells(23807208).