NUDC

nuclear distribution C, dynein complex regulator

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000090273
UniProt:
Q9Y266
OMIM:
610325

Cilia effects upon perturbation of NUDC

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Inhibits ciliogenesis

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, flagella, nucleus

References: PMID:26704451

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Regulates actin dynamics and organisation, as well as ciliogenesis, by stabilising cofilin 1. Suppresses ciliogenesis in mammals (26704451).