NUDC

nuclear distribution C, dynein complex regulator

Ensembl:
ENSG00000090273
UniProt:
Q9Y266
OMIM:
610325

Cilia effects upon perturbation of NUDC

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Inhibits ciliogenesis

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, flagella, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Regulates actin dy mics and organisation, as well as ciliogenesis, by stabilising cofilin 1. Suppresses ciliogenesis in mammals (26704451).

Model organism evidence

Danio rerio (1 reference)

NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.

PMIDs: 26704451