NUDCD2

Cilia effects upon perturbation of NUDCD2

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.84) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.23) PMID:29459680
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.68) PMID:41160700

Phenotypes

Mouse phenotype:

preweaning lethality, incomplete penetrance, pretal lethality, preweaning lethality, complete penetrance

Ciliopathy associations

• Nephronophthisis

Subcellular localization

basal body

Functional category

• Ciliary assembly/disassembly
• Protein processing & maturation

Function

NudCL2 and CP110 are removed from mother basal bodys during cilliogenesis (34480124).