NUDCD3

Cilia effects upon perturbation of NUDCD3

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.59) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=350, lfc=-2.84) PMID:30270045

Phenotypes

Mouse phenotype:

increased circulating insulin level, increased red blood cell distribution width, decreased circulating glucose level, increased blood urea nitrogen level

Mouse ciliopathy phenotype:

increased circulating creatinine level

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Protein processing & maturation

Function

NUDCD3 has localized in ciliary tip, primary cilia.