NUMA1

nuclear mitotic apparatus protein 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000137497
OMIM:: 164009
Synonyms:: NUMA

Subcellular localization

Nucleoplasm

References: PMID:33258871

Functional category

Motors (dynein/kinesin)
Ciliary assembly/disassembly
Cilia–cytoskeleton/adhesion links

Function

Smo activates the Gαi-LGN-NuMA-dynein axis, causing accumulation of a portion of OFD1 at centrioles in early ciliogenesis. Both pathways are critical for redistribution of BBS4 from satellites to centrioles, which is also mediated by OFD1 centriolar translocation. Notably, different Smo agonists, which activate Smo distinctly, activate one or the other of these pathways, only in combination they recapitulate the activity of Hh ligand. These studies provide new insight into physiological stimuli (Hh) that activate autophagy and promote ciliogenesis and introduce a novel role for the Gαi-LGN-NuMA-dynein complex in this process(33258871).

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