NUMB

NUMB endocytic adaptor protein

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000133961
UniProt:
P49757
OMIM:
603728
Synonyms:
C14ORF41

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.35) PMID:20393562

Subcellular localization

cilia, nucleus

References: PMID:25319694

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Potential role in regulation of protein trafficking and polarised delivery of Cng channels to photoreceptor cilia, through recycling endosomes for delivery to OS plasma membrane (25319694 ).