NUMB

NUMB endocytic adaptor protein

Ensembl:
ENSG00000133961
UniProt:
P49757
OMIM:
603728
Synonyms:
C14ORF41

Cilia effects upon perturbation of NUMB

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.35) PMID:20393562

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Potential role in regulation of protein trafficking and polarised delivery of Cng channels to photoreceptor cilia, through recycling endosomes for delivery to OS plasma membrane (25319694 ).

Model organism evidence

Mus musculus (2 references)

IFT20 is a subunit of the intraflagellar transport (IFT) system essential for the formation and function of cilia.

Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.

PMIDs: 33748116, 25319694