NUP85

nucleoporin 85

Ensembl:
ENSG00000125450
UniProt:
Q9BW27
OMIM:
170285
Synonyms:
FLJ12549, NUP75

Cilia effects upon perturbation of NUP85

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.51) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Metabolism
  • T cell biology
  • Viral interactions
  • Cell migration & adhesion
  • Transcription regulation

Function

NUP85 has localized in basal body.