NUP93

Cilia effects upon perturbation of NUP93

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Loss of cilia

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-24.89) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.27, ciliated=20.3%) PMID:26595381

Phenotypes

Mouse phenotype:

embryonic lethality prior to organogenesis

Subcellular localization

nucleus, transition zone

References: PMID:22388888, PMID:33065118

Functional category

• Ciliary assembly/disassembly
• Metabolism
• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)
• Transition zone
• Transcription regulation

Function

Inner ring nucleoporin, component of ciliary pore complex that regulares protein transport into cilia (22388888). Involved in proper left-right patterning in developing embryos (33065118).