ODAD2

outer dynein arm docking complex subunit 2

Ensembl:: ENSG00000169126
UniProt:: Q5T2S8
OMIM:: 615408
Synonyms:: ARMC4, CILD23, DKFZP434P1735, FLJ10376, FLJ10817

Cilia effects upon perturbation of ODAD2

Phenotypes

Mouse phenotype:: small spleen, hypoplasia
Mouse ciliopathy phenotype:: small kidney, male infertility
Human ciliopathy phenotype:: primary ciliary dyskinesia

Ciliopathy associations

Primary Ciliary Dyskinesia

Subcellular localization

basal body, cilia

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

PCD with randomisation of body axis 23849778. Causes outer dynein arm defects in motile cilia 24203976

Model organism evidence

Drosophila (1 reference)

Phosphoproteomic analyses reveal that dTSSK2 coordinates sperm flagella assembly and motility by phosphorylating proteins involved in microtubule organization, organelle assembly, and flagella structure.

PMIDs: 40335644

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