ODAD3

outer dynein arm docking complex subunit 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000198003
UniProt:
A5D8V7
OMIM:
615956
Synonyms:
MGC20983, ODA10, CILD30, CCDC151

Cilia effects upon perturbation of ODAD3

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Longer cilia
Overexpression effect:
Unknown

Phenotypes

Mouse phenotype:
impaired glucose tolerance, preweaning lethality, incomplete penetrance, decreased bone mineral density, abnormal bone structure
Human ciliopathy phenotype:
primary ciliary dyskinesia

Ciliopathy associations

  • Primary Ciliary Dyskinesia

References: PMID:25224326, PMID:31383820, PMID:25192045, PMID:30504913

Subcellular localization

cilia, axoneme, motile cilium, outer dynein arm docking complex

References: PMID:25192045

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion
  • Motile cilium & axoneme

Function

Ensures correct attachment of outer dynein arm (ODA) complexes to and is required for proper motile and non-motile functions, controls intraflagellar transport (IFT)- dependent dynein arm assembly and regulates primary cilia lenght in mammals. Required for the correct establishment of left-right asymmetry. When mutated causes PCD by disruption of the outer dynein arm docking complex formation (25192045 )